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Category:Drive (computer file system)gamma-Aminobutyric acidB receptor blocker and GABAB receptor agonist properties of 2-hydroxy-N-(1,4-dihydro-4-phenyl-1-4-piperidinyl)acetamide.
The gamma-aminobutyric acidB receptor blocker (+/-)2-hydroxy-N-(1,4-dihydro-4-phenyl-1-4-piperidinyl)acetamide is a new psychotropic agent. This compound (300-600 mg/kg) and a vehicle control were investigated for receptor binding and anticonvulsant properties in mice. The compound is a potent inhibitor of 3H-GABA binding to rat brain membranes (IC50 = 3.4 +/- 0.4 microM) and this inhibition was displaced by GABA. The compound antagonized the cataleptogenic effects of GABAB receptor agonists in mice, indicating that it is a competitive antagonist at the receptor. The compound was also a potent anticonvulsant in the maximal electroshock (MES) test when given at doses of 30 and 100 mg/kg. In the subcutaneous pentylenetetrazol (s.c. PTZ) test, the compound reduced the ED50 value for pentylenetetrazol and increased the latency to seizure. These results suggest that (+/-)2-hydroxy-N-(1,4-dihydro-4-phenyl-1-4-piperidinyl)acetamide is a potent GABAB receptor antagonist that is anticonvulsant in vivo.Share on Facebook
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Since the start of the new year, we’ve been given new details about Ridley Scott’s $140 million space thriller The Martian, as well as news on a September 3 release.
The Martian stars Matt Damon as astronaut Mark Watney, who is marooned after a manned mission to Mars goes awry. The Guardian wrote up some of the major plot points back in January, and now Deadline (via Variety) has revealed that the recently-filmed movie is very loosely based on the real-life events that occurred to NASA astronaut Mark Watney.
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