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In biomedicine, nanoparticles (NPs) are utilized in numerous fields. With immunostimulation potential, NP-based therapeutics could provide higher efficacy while maintaining safety. The antigen-presenting function of dendritic cells (DCs) is an important mechanism for the initiation and regulation of T cell-mediated immunity. A DC will engage T cells for antigen presentation only when external signals induce maturation of the DC. Currently, NPs are known to have potential for regulating the function of DCs; however, the effects of magnetic NPs (MNPs) on DCs are still largely unclear. In this study, we used two murine models to observe the effects of MNPs on the function of DCs. H2Kd mRNA and protein expression increased on the dendritic cell surface after incubation with MNPs. Likewise, signal pathway analysis revealed that the protein expression of Toll-like receptor 2, protein tyrosine kinase (Syk), phospholipase C (PLC), and mitogen-activated protein kinase (MAPK) were upregulated after incubation with MNPs. We also examined the effects of MNPs on the maturation of DCs, including maturation protein expression, maturation index, the ability of DCs to induce T cell proliferation, and cytokine expression. The results demonstrated that MNPs could suppress the maturation of DCs. Finally, we examined the effects of MNPs on the helper T cell-mediated immune response in vivo. The results indicated that MNPs in the